Water → 6,7-Dimethyl-5-methoxy-1,3-dihydro-2H-indole-2-one

HRID 1743397노트

반응식

HRID 1743397 반응식
[CH3:1][C:2]1[C:10]([CH3:11])=[C:9]2[C:5]([CH:6](SC)[C:7](=[O:12])[NH:8]2)=[CH:4][C:3]=1[O:15][CH3:16].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O.C1(C)C(S(O)(=O)=O)=CC=CC=1.O>ClCCl>[CH3:1][C:2]1[C:10]([CH3:11])=[C:9]2[C:5]([CH2:6][C:7](=[O:12])[NH:8]2)=[CH:4][C:3]=1[O:15][CH3:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 11776TriphenylphosphineHCID 124969952-Methylbenzenesulfonic acid hydrateHCID 222380776,7-Dimethyl-5-methoxy-3-(methylthio)-1,3-dihydro-2H-indole-2-one

생성물 1

HCID 222380866,7-Dimethyl-5-methoxy-1,3-dihydro-2H-indole-2-one수율 72.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 6,7-dimethyl-5-methoxy-3(methylthio)-1,3-dihydro-2H-indole-2-one (30 g, 126 mmol) in dichloromethane (600 mL) were added triphenylphosphine (40 g, 153 mmol) and toluenesulfonic acid monohydrate (29 g, 153 mmol) at room temperature, and the mixture was stirred for 3 hours. The reaction solution was poured into cool water, and the precipitated crystals were filtered. The crystals were washed with dichloromethane and water to obtain 17.5 g of the title compound.

후처리

  1. additionThe reaction solution was poured
  2. filtrationthe precipitated crystals were filtered
  3. washThe crystals were washed with dichloromethane and water

출처 및 근거

ORD 기록
ord-ad8c36e386b34d36a1b6ea7ae5f1c0fb
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07008940B1

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