1,1,3-Trichloropropene → 2-(3,3-Dichloro-2-propenyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile

HRID 1743559노트

반응식

HRID 1743559 반응식
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:15]=[CH:14][C:7]([CH2:8][CH:9]([C:12]#[N:13])[C:10]#[N:11])=[CH:6][CH:5]=1.[H-].[Na+].[Cl:20][C:21]([Cl:25])=[CH:22][CH2:23]Cl>CN(C)C=O>[Cl:20][C:21]([Cl:25])=[CH:22][CH2:23][C:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([O:3][C:2]([F:16])([F:17])[F:1])=[CH:15][CH:14]=1)([C:12]#[N:13])[C:10]#[N:11]

참가 물질

5

반응물 3

HCID 173781,1,3-TrichloropropeneHCID 24758Sodium hydrideHCID 22235052(4-(Trifluoromethoxy)benzyl)malononitrile

생성물 1

HCID 222349852-(3,3-Dichloro-2-propenyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile수율 28%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 0.20 g of (4-(trifluoromethoxy)benzyl)malononitrile, 5 ml of N,N-dimethylformamide, 50 mg of sodium hydride (60% in oil), and 0.17 ml of 1,1,3-trichloropropene, and according to the process described in the Production Example 1, there was obtained 80 mg of 2-(3,3-dichloro-2-propenyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile (the present compound (28)).

출처 및 근거

ORD 기록
ord-5cf97dab61754e9e98007740576c729b
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07011838B2

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