Hydrochloric Acid → 4-[2-(3,8-Diazabicyclo[3.2.1]oct-8-yl)ethoxy]benzonitrile

HRID 1743721노트

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HRID 1743721 반응식
[C:1]([C:3]1[CH:26]=[CH:25][C:6]([O:7][CH2:8][CH2:9][N:10]2[CH:15]3[CH2:16][CH2:17][CH:11]2[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14]3)=[CH:5][CH:4]=1)#[N:2].Cl>C(OCC)(=O)C>[CH:15]12[N:10]([CH2:9][CH2:8][O:7][C:6]3[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:26][CH:25]=3)[CH:11]([CH2:17][CH2:16]1)[CH2:12][NH:13][CH2:14]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22235539Tert-butyl 8-[2-(4-cyanophenoxy)ethyl]-3,8-diazabicyclo[3.2.1]octane-3-carboxylate

생성물 1

HCID 222356414-[2-(3,8-Diazabicyclo[3.2.1]oct-8-yl)ethoxy]benzonitrile수율 73%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

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온도
0 °C

실험 절차

tert-Butyl 8-[2-(4-Cyanophenoxy)ethyl]-3,8-diazabicyclo[3.2.1]octane-3-carboxylate (1.35 g, 3.8 mmol; from step (b) above) was dissolved in ethyl acetate (30 mL). The solution was cooled to 0° C., ethyl acetate (30 mL) saturated with gaseous HCl was added, and the resulting mixture stirred at r.t for 15 h. The solvent was evaporated before CHCl3 was added. The mixture was extracted with K2CO3 solution, separated, dried and evaporated to give 0.7 g (73%) of the title compound.

후처리

  1. customThe solvent was evaporated before CHCl3
  2. additionwas added
  3. extractionThe mixture was extracted with K2CO3 solution
  4. customseparated
  5. customdried
  6. customevaporated

출처 및 근거

ORD 기록
ord-0eb0e1f6ff0345b1ab5e5787fccf8f6f
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07012074B2

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