Sodium Carbonate → 2-Amino-6-methyl-6-nitroheptanoic acid

HRID 1744014노트

반응식

HRID 1744014 반응식
[CH3:1][C:2]([N+:14]([O-:16])=[O:15])([CH3:13])[CH2:3][CH2:4][CH2:5][CH:6]1[NH:10]C(=O)N[C:7]1=[O:12].[OH-].[Na+].[OH-].[K+].C(=O)([O-])[O-:22].[Na+].[Na+].C(=O)([O-])[O-].[K+].[K+].[OH-].[Ca+2].[OH-].[OH-].[Ba+2].[OH-]>>[NH2:10][CH:6]([CH2:5][CH2:4][CH2:3][C:2]([CH3:1])([N+:14]([O-:16])=[O:15])[CH3:13])[C:7]([OH:12])=[O:22]

참가 물질

8

반응물 7

HCID 10340Sodium CarbonateHCID 11430Potassium CarbonateHCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 6093208Calcium HydroxideHCID 6093286Barium hydroxideHCID 99427025-(4-Methyl-4-nitropentyl)hydantoin2회

생성물 1

HCID 219723372-Amino-6-methyl-6-nitroheptanoic acid

실험 절차

5-(4-Methyl-4-nitropentyl)hydantoin is hydrolyzed with alkali to give 2-amino-6-methyl-6-nitroheptanoic acid (see JP-A-11-140076). For example, 5-(4-methyl-4-nitropentyl)hydantoin is hydrolyzed in an aqueous solution preferably in the presence of 1–3 equivalents of alkali, such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, calcium hydroxide, barium hydroxide and the like, relative to 5-(4-methyl-4-nitropentyl)hydantoin generally at 20–200° C., preferably 100–150° C. The reaction mixture is concentrated to dryness to give 2-amino-6-methyl-6-nitroheptanoic acid. The obtained 2-amino-6-methyl-6-nitroheptanoic acid can be isolated and/or purified by a conventional method, such as crystallization, chromatography and the like, but generally, can be used in the next step without isolation and/or purification.

후처리

  1. customgenerally at 20–200° C.
  2. custompreferably 100–150° C
  3. concentrationThe reaction mixture is concentrated to dryness

출처 및 근거

ORD 기록
ord-f667e67a869a4be18fe82e8218cc296d
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07012152B2

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