2-Nitropropane → 4-Methyl-4-nitrovaleronitrile

HRID 1744028노트

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HRID 1744028 반응식
[C:1](#[N:4])[CH:2]=[CH2:3].[N+:5]([CH:8]([CH3:10])[CH3:9])([O-:7])=[O:6]>[Cl-].C([N+](C)(C)C)CCCCCCCCCCCCCCC.[OH-].[Na+]>[CH3:9][C:8]([N+:5]([O-:7])=[O:6])([CH3:10])[CH2:3][CH2:2][C:1]#[N:4]

참가 물질

5

반응물 2

HCID 3982-NitropropaneHCID 7855Acrylonitrile

생성물 1

HCID 38791404-Methyl-4-nitrovaleronitrile수율 64.6%

시약·촉매·용매 2

HCID 8154Hexadecyltrimethylammonium chloride촉매HCID 14798Sodium Hydroxide용매

실험 절차

Acrylonitrile (6.0 g, 113 mmol), 2-nitropropane (12.0 g, 135 mmol) and hexadecyltrimethyl ammonium chloride (2.0 g) were stirred in a 0.1N aqueous sodium hydroxide solution (200 ml) overnight at room temperature. The layers were separated and the aqueous layer was extracted twice with methylene chloride (50 ml). The combined organic layer was washed with saturated brine (30 ml). The solvent was evaporated and the residue was dried to give oily 4-methyl-4-nitrovaleronitrile (10.4 g, 73 mmol, yield 64.6%).

후처리

  1. customThe layers were separated
  2. extractionthe aqueous layer was extracted twice with methylene chloride (50 ml)
  3. washThe combined organic layer was washed with saturated brine (30 ml)
  4. customThe solvent was evaporated
  5. customthe residue was dried

출처 및 근거

ORD 기록
ord-0ef10877582c4bdab499913352680583
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07012152B2

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