Sodium Hydroxide → 4-Trifluoromethylnicotinamide
반응식
[F:1][C:2]([F:13])([F:12])[C:3](=O)[CH:4]=[CH:5][NH:6][CH:7]=[CH:8][C:9]#[N:10].[OH-].[Na+].CCCCCC.CC(C)=[O:24]>CO>[F:1][C:2]([F:13])([F:12])[C:3]1[C:8]([C:9]([NH2:10])=[O:24])=[CH:7][N:6]=[CH:5][CH:4]=1참가 물질
5
실험 절차
3-[(4,4,4-Trifluoro-3-oxo-1-butenyl)amino]-2propenenitrile (a mixture of IIa and IIb; 1.90 g, 10 mmol) was dissolved in methanol (15 ml), and sodium hydroxide (600 mg, 15 mmol) was added. The mixture was heated under reflux for 6 hours. The reaction mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (a eluting solvent: hexane/acetone=1/1) to obtain 1.25 g (yield 65.6%) of the title compound.
후처리
- temperatureThe mixture was heated
- temperatureunder reflux for 6 hours
- concentrationThe reaction mixture was concentrated under reduced pressure
- customThe resulting residue was purified by silica gel column chromatography (a eluting solvent
출처 및 근거
- ORD 기록
- ord-5d615dc0d391490cb063e8c10c01152d
- 출처 데이터셋
- uspto-grants-2006_03
- 특허 번호
- US07015236B2
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