2-Propenoic acid, 2-(acetyloxy)-, methyl ester → (S)-methyl 2-methylcarbonyloxypropanoate

HRID 1744413

반응식

HRID 1744413 반응식
[C:1]([O:4][C:5](=[CH2:10])[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].[H][H]>[B-](F)(F)(F)F.C1C2C=CC1C=C2.C1C2C=CC1C=C2.[Rh].PP.CO>[CH3:2][C:1]([O:4][C@@H:5]([CH3:10])[C:6]([O:8][CH3:9])=[O:7])=[O:3]

참가 물질

6

반응물 2

HCID 111372772-Propenoic acid, 2-(acetyloxy)-, methyl esterHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 11051803(S)-methyl 2-methylcarbonyloxypropanoate

시약·촉매·용매 3

HCID 887Methanol용매HCID 139283Diphosphane용매HCID 10915722Bis(norbornadiene)rhodium(I) tetrafluoroborate용매

실험 절차

In a 50 ml Schlenk vessel, Rh(nbd)2BF4 (5.2 mg, 1 mol %) and the diphosphine ligand (1 mol %) were dissolved in MeOH (10 ml) under argon. After all of the rhodium complex had gone into solution, methyl 2-acetoxyacrylate (200 mg, 1.39 mmol) was added. The Schienk vessel was subsequently connected via a three-way stopcock with a hydrogen balloon and an oil pump and the inert gas atmosphere was replaced by hydrogen. The reaction mixture was stirred at room temperature for 20 h and the solvent was then distilled off in an oil pump vacuum. The residue was purified by bulb tube distillation. The ester (S)-8 was obtained as a colorless oil in quantitative yield.

후처리

  1. additionwas added
  2. distillationthe solvent was then distilled off in an oil pump vacuum
  3. customThe residue was purified by bulb tube
  4. distillationdistillation

출처 및 근거

ORD 기록
ord-0489fe46fcc448b680af3d1bea2f9f8d
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07015342B2

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