Water → 1-(4-fluorophenyl)-3-methyl-1H-pyrazole-4-carboxylic acid
반응식
O.[F:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[C:12]([C:14]([O:16]CC)=[O:15])[C:11]([CH3:19])=[N:10]2)=[CH:5][CH:4]=1.[OH-].[Na+]>C(O)C>[F:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH:13]=[C:12]([C:14]([OH:16])=[O:15])[C:11]([CH3:19])=[N:10]2)=[CH:7][CH:8]=1참가 물질
5
실험 절차
To a mixed solvent of ethanol (40 ml) and water (40 ml) were added ethyl 1-(4-fluorophenyl)-3-methylpyrazole-4-carboxylate (8.5 g) and sodium hydroxide (1.66 g), and the mixture was stirred at a refluxing temperature for 2 h. After the reaction, ethanol was evaporated and to the residue was added dilute hydrochloric acid. The obtained solid was recrystallized from aqueous methanol solution to give the title compound, melting point: 194–195° C.
후처리
- customwas evaporated and to the residue
- additionwas added dilute hydrochloric acid
- customThe obtained solid was recrystallized from aqueous methanol solution
출처 및 근거
- ORD 기록
- ord-acb36e67ecfe48ac937268c9f2f5f074
- 출처 데이터셋
- uspto-grants-2006_03
- 특허 번호
- US07015218B1
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