Sodium Hydroxide → 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

HRID 1744471노트

반응식

HRID 1744471 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13]([O:15]CC)=[O:14])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[N:9]2)=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 14994516Ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

생성물 1

HCID 31596171-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid수율 95.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Ethyl 1-(4-fluorophenyl)pyrazole-4-carboxylate (10.6 g) was dissolved in a mixed solvent of ethanol (80 ml) and water (80 ml), and sodium hydroxide (2.2 g) was added. The mixture was stirred at a refluxing temperature for 30 min. After evaporation of ethanol, dilute hydrochloric acid was added to the residue. The obtained solid was recrystallized from aqueous methanol solution to give the title compound (8.9 g), melting point: 244–247° C.

후처리

  1. additionwas added
  2. customAfter evaporation of ethanol, dilute hydrochloric acid
  3. additionwas added to the residue
  4. customThe obtained solid was recrystallized from aqueous methanol solution

출처 및 근거

ORD 기록
ord-784da902b3d9492aa6c5c20db22b11e8
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07015218B1

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