Sodium Hydroxide → 1-(4-Fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

HRID 1744477노트

반응식

HRID 1744477 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][C:10]([CH3:18])=[N:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]([CH3:18])=[N:9]2)=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 22227950Ethyl 1-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

생성물 1

HCID 222280661-(4-Fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid수율 78.9%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Ethyl 1-(4-fluorophenyl)-3-methylpyrazole-5-carboxylate (2 g) was dissolved in a mixed solvent of ethanol (10 ml) and water (10 ml) and sodium hydroxide (0.4 g) was added. The mixture was stirred at a refluxing temperature for 30 min. Ethanol was evaporated and to the residue was added dilute hydrochloric acid. The obtained solid was recrystallized from aqueous methanol solution to give the title compound (1.4 g), melting point: 188° C.

후처리

  1. additionwas added
  2. customEthanol was evaporated and to the residue
  3. additionwas added dilute hydrochloric acid
  4. customThe obtained solid was recrystallized from aqueous methanol solution

출처 및 근거

ORD 기록
ord-c6b18735a6df46afaf111fe7dabe6717
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07015218B1

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