Sodium Hydroxide → 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid

HRID 1744481노트

반응식

HRID 1744481 반응식
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][C:4]([C:13]([O:15]C)=[O:14])=[N:3]1.[OH-].[Na+]>C(O)C.O>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][C:4]([C:13]([OH:15])=[O:14])=[N:3]1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 21766260Methyl 1-methyl-5-phenyl-1h-pyrazole-3-carboxylate

생성물 1

HCID 75376191-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid수율 65.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Methyl 1-methyl-5-phenylpyrazole-3-carboxylate (3.6 g) was dissolved in a mixed solvent of ethanol (20 ml) and water (20 ml) and sodium hydroxide (0.8 g) was added. The mixture was stirred at a refluxing temperature for 30 min. Ethanol was evaporated and to the residue was added dilute hydrochloric acid. The obtained solid was recrystallized from aqueous methanol solution to give the title compound (2.2 g), melting point: 149–150° C.

후처리

  1. additionwas added
  2. customEthanol was evaporated and to the residue
  3. additionwas added dilute hydrochloric acid
  4. customThe obtained solid was recrystallized from aqueous methanol solution

출처 및 근거

ORD 기록
ord-738d63e9dd764f438106eba37cc859f0
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07015218B1

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