Sodium Hydroxide → Sodium Nalpha-[3-(2,6-Difluorophenyl)acryloyl]-L-Tryptophanate

HRID 1746540노트

반응식

HRID 1746540 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH:9]=[CH:10][C:11]([NH:13][C@H:14]([C:25]([O:27]C)=[O:26])[CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[NH:18][CH:17]=1)=[O:12].[OH-].[Na+:30]>CO>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH:9]=[CH:10][C:11]([NH:13][C@H:14]([C:25]([O-:27])=[O:26])[CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[NH:18][CH:17]=1)=[O:12].[Na+:30]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86655446Methyl Nalpha-[3-(2,6-Difluorophenyl)acryloyl]-L-Tryptophanate

생성물 1

HCID 86655492Sodium Nalpha-[3-(2,6-Difluorophenyl)acryloyl]-L-Tryptophanate수율 68%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The same procedures as in Example 60 were carried out from the compound obtained in Example 13 (3.9 g), 1 mol/L of an aqueous sodium hydroxide solution (15 mL), and methanol (150 mL), to give the captioned compound (2.7 g, 68%) as an amorphous solid product.

출처 및 근거

ORD 기록
ord-cce4a6d800b7490e9be972fd4d5ed303
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150510B2

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