O-Toluidine → 6-chloro-N-(2-methylphenyl)pyrimidine-4-carboxamide

HRID 1746656

반응식

HRID 1746656 반응식
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8](Cl)=[O:9])[CH:3]=1.[NH2:11][C:12]1[C:13]([CH3:18])=[CH:14][CH:15]=[CH:16][CH:17]=1.CCN(C(C)C)C(C)C>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[O:9])[CH:3]=1

참가 물질

5

반응물 3

HCID 7242O-ToluidineHCID 81531DiisopropylethylamineHCID 184220986-Chloropyrimidine-4-carbonyl chloride

생성물 1

HCID 594470936-chloro-N-(2-methylphenyl)pyrimidine-4-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A cooled (0° C.) solution of 6-chloropyrimidine-4-carbonyl chloride (26.76 g; 151 mmol), obtained as described above for Intermediate 7 step 1, in anhydrous DCM (270 ml) was treated dropwise over 25 minutes with a solution of o-toluidine (13.6 ml; 126.0 mmol) and DIEA (43.4 ml; 252 mmol) in anhydrous DCM (100 mL). At the end of addition, the reaction mixture was washed with water then brine, dried over MgSO4, filtered and dried under vacuum to afford the title compound used without further purification as a brown solid. 1H NMR (300 MHz, DMSO-d6) δ 10.47 (1H, br s), 9.32 (1H, d, J=1.0 Hz), 8.25 (1H, d, J=1.0 Hz), 7.65-7.63 (1H, m), 7.34-7.19 (3H, m), 2.31 (3H, s). MS (ESI+): 248.0; MS (ESI−): 246.1. HPLC (Condition A): Rt 4.19 min (HPLC purity 96.0%).

후처리

  1. customobtained
  2. additionAt the end of addition
  3. washthe reaction mixture was washed with water
  4. dry with materialbrine, dried over MgSO4
  5. filtrationfiltered
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-6481917ed77b4859acfe52412bb441c8
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150519B2

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