Hydrogen Bromide → 6-(2-aminoethyl)pyridin-2(1H)-one hydrobromide

HRID 1747044노트

반응식

C[O:2][C:3]1[N:8]=[C:7]([CH2:9][CH2:10][NH2:11])[CH:6]=[CH:5][CH:4]=1.[BrH:12]>>[BrH:12].[NH2:11][CH2:10][CH2:9][C:7]1[NH:8][C:3](=[O:2])[CH:4]=[CH:5][CH:6]=1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 212435192-(6-Methoxypyridin-2-yl)ethan-1-amine

생성물 1

HCID 684507096-(2-aminoethyl)pyridin-2(1H)-one hydrobromide

반응 조건

온도: 80 °C

실험 절차

To 700 mg of 2-(6-methoxypyridin-2-yl)ethylamine was added 10 ml of a 47% aqueous hydrogen bromide solution, followed by stirring at 80° C. for 60 hours. After evaporating the solvent, the residue was washed with diethyl ether to obtain 1.21 g of a 6-(2-aminoethyl)pyridin-2(1H)-one hydrobromide as a pale brown solid.

후처리

customAfter evaporating the solvent
washthe residue was washed with diethyl ether

출처 및 근거

ORD 기록: ord-a90f43e583a84e3e8228c9acf5d5ea30
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09150541B2

반응 노트

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