Hydrochloric Acid → HCID 59497358, 화합물

HRID 1747284노트

반응식

HRID 1747284 반응식
[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8](C(C)=C)[C:7]1=[O:18].CO.O.Cl>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7]1=[O:18]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 59497548HCID 59497548, 화합물

생성물 1

HCID 59497358HCID 59497358, 화합물수율 93%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
60 °C

실험 절차

3-(3-Isopropenyl-2-oxo-2,3-dihydro-benzimidazol-1-yl)-propionic acid methyl ester (2.2 g, 8.3 mmol) was treated with MeOH (5 mL) followed by water (5 mL) To this heterogeneous reaction mixture was added 37% hydrochloric acid (4 mL). This reaction mixture was heated to 60° C. for 20 min. The reaction remained as a clear homogeneous solution after heating. The reaction mixture was diluted with CH2Cl2 and washed with water. The organic phase was dried over Na2SO4 and concentrated to afford 1.7 g of the desired product as a white solid. This product was used for the next reaction without further purification.

후처리

  1. temperatureafter heating
  2. washwashed with water
  3. dry with materialThe organic phase was dried over Na2SO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-27f3eaf53ede4e818bc1cdb73af695d0
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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