Hydrochloric Acid → HCID 59497358, 화합물

HRID 1747349노트

반응식

HRID 1747349 반응식
[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8](C(C)=C)[C:7]1=[O:18].Cl>C(O)C.O.ClCCl>[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7]1=[O:18]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 59497548HCID 59497548, 화합물

생성물 1

HCID 59497358HCID 59497358, 화합물수율 86.4%

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매2회HCID 6344Dichloromethane용매

반응 조건

온도
60 °C

실험 절차

To a stirred solution of 3-(3-Isopropenyl-2-oxo-2,3-dihydro-benzimidazol-1-yl)-propionic acid methyl ester (4.8 g, 18.4 mmol) in ethanol (30 ml) and water (30 ml) was added 37% hydrochloric acid (24 ml). The resulting solution was warmed to 60° C. for twenty minutes and cooled. The reaction was diluted with dichloromethane and water. The layers were separated and the organic phase was dried (Na2SO4), filtered and concentrated to give 3.5 g (86%) of the desired product as an oil which solidified on standing. Used without further purification.

후처리

  1. temperaturecooled
  2. customThe layers were separated
  3. dry with materialthe organic phase was dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c0a89cf2edb14a2bbeb4955d9e7b8a24
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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