1-1,2-Benzisoxazol-3-ylmethyl-3-isopropenyl-1,3-dihydro-benzimidazol-2-one → 1-1,2-Benzisoxazol-3-ylmethyl-1,3-dihydro-benzimidazol-2-one

HRID 1747356노트

반응식

HRID 1747356 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13](C(C)=C)[C:12]2=[O:23])=[N:2]1>C(O)C.O.Cl>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[NH:13][C:12]2=[O:23])=[N:2]1

참가 물질

5

반응물 1

HCID 594976931-1,2-Benzisoxazol-3-ylmethyl-3-isopropenyl-1,3-dihydro-benzimidazol-2-one

생성물 1

HCID 594976021-1,2-Benzisoxazol-3-ylmethyl-1,3-dihydro-benzimidazol-2-one수율 89%

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매HCID 962Water용매2회

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온도
60 °C

실험 절차

The 1-1,2-benzisoxazol-3-ylmethyl-3-isopropenyl-1,3-dihydro-benzimidazol-2-one (0.26 g, 0.85 mmol) was diluted with ethanol (2 ml), water (2 ml) and 37% HCl (1 ml). The resulting mixture was warmed to 60° C. for 1 h and cooled to ambient temperature. The reaction was diluted with water and the product was extracted into dichloromethane. The layers were separated and the organic phase was dried (MgSO4). Filtration and concentration gave 0.20 g (89%) of the desired product which was used without further purification.

후처리

  1. temperaturecooled to ambient temperature
  2. extractionthe product was extracted into dichloromethane
  3. customThe layers were separated
  4. dry with materialthe organic phase was dried (MgSO4)
  5. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-88f96f7bd5d4421e9a825a9a6eb958e6
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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