To a stirred solution of 3-[3-(4-Chloro-1,2,3-trimethyl-1H-indol-7-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoic acid ethyl ester (25 mg, 0.05 mmol) in THF (5 ml) and water (1 ml) was added lithium hydroxide monohydrate (20 mg, 0.48 mmol). The resulting mixture was stirred at ambient temperature until all of the starting material was consumed. After this time the reaction was concentrated to low volume and diluted with water (5 ml) and acetic acid (0.2 ml). The resulting solid was collected via filtration and suspended in acetonitrile/water. The solid was collected once more via filtration and dried on house vacuum at 70° C. to give 10 mg (43%) of the desired product. LCMS (ESMS): m/z 454.96 (M+H+).
