Lithium Hydroxide → HCID 59497611, 화합물

HRID 1747476노트

반응식

HRID 1747476 반응식
C[O:2][C:3](=[O:28])[CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]([CH2:15][C:16]2[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]3[C:17]=2[CH2:18][C:19](=[O:26])[NH:20]3)[C:7]1=[O:27].[OH-].[Li+]>O.O1CCOCC1>[Cl:25][C:23]1[CH:22]=[C:21]2[C:17]([CH2:18][C:19](=[O:26])[NH:20]2)=[C:16]([CH2:15][N:8]2[C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:6]([CH2:5][CH2:4][C:3]([OH:28])=[O:2])[C:7]2=[O:27])[CH:24]=1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 67360378HCID 67360378, 화합물

생성물 1

HCID 59497611HCID 59497611, 화합물수율 36%

시약·촉매·용매 1

HCID 218864351,4-Dioxane--water (1/1)용매

실험 절차

3-[3-(6-Chloro-2-oxo-2,3-dihydro-1H-indol-4-ylmethyl)-2-oxo-2,3-dihydro-benzoimidazol-1-yl]-propionic acid methyl ester (34 mg 0.09 mmol) is dissolved in dioxane water (2 mL/2 mL) and lithium hydroxide (18 mg, 0.45 mmol) is added in one portion. The reaction is stirred for one hour then the solvents evaporated in vacuo. The crude material is purified by preparative reverse phase LC to give the title compound (12 mg 0.03 mmol, 36%). LCMS (ESMS): m/z 387.1 (M+H+).

후처리

  1. customthe solvents evaporated in vacuo
  2. customThe crude material is purified by preparative reverse phase LC

출처 및 근거

ORD 기록
ord-f9ed6f589a7f408b99d44975ba774f83
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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