Dimethylformamide → 3-Bromo-5-phenylpyrazin-2(1H)-one

HRID 1747777노트

반응식

HRID 1747777 반응식
[C:1]1([C:7]2[N:8]=[CH:9][C:10](=[O:13])[NH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:14]N1C(=O)CCC1=O.CN(C=O)C>O>[Br:14][C:9]1[C:10](=[O:13])[NH:11][CH:12]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 67184N-bromobutanimideHCID 5990375-phenyl-1H-pyrazin-2-one

생성물 1

HCID 124535473-Bromo-5-phenylpyrazin-2(1H)-one수율 14.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 5-phenylpyrazin-2(1H)-one (0.86 g), N-bromosuccinimide (0.89 g) and DMF (16 mL) was stirred at room temperature for 2 hr. The reaction mixture was diluted with water, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was washed with hexane to give the title compound (0.18 g).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe extract was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. washThe residue was washed with hexane

출처 및 근거

ORD 기록
ord-e3f95176644442dd8ee68b8a0625502d
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150588B2

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