1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 89586102, 화합물

HRID 1747835노트

반응식

HRID 1747835 반응식
[CH3:1][O:2][C:3]1[C:4](=[O:22])[C:5]([C:19](O)=[O:20])=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[CH:8]=1.[CH3:23][C:24]([C:27]([O:29][CH3:30])=[O:28])([CH3:26])[NH2:25].C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.C(N(CC)C(C)C)(C)C>C1COCC1.O>[CH3:1][O:2][C:3]1[C:4](=[O:22])[C:5]([C:19]([NH:25][C:24]([CH3:26])([C:27]([O:29][CH3:30])=[O:28])[CH3:23])=[O:20])=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[CH:8]=1

참가 물질

8

반응물 5

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 4186341Methyl 2-amino-2-methylpropanoateHCID 594362475-Methoxy-4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylic acid

생성물 1

HCID 89586102HCID 89586102, 화합물수율 85.1%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 5-methoxy-4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylic acid (300 mg), methyl 2-methylalaninate (134 mg), HOBt (219 mg), WSC (275 mg) and N,N-diisopropylethylamine (0.834 mL) in THF (3.18 mL) was stirred at room temperature for 17 hr, and water was added. The precipitate was collected by filtration, and washed with water and hexane to give the title compound (336 mg).

후처리

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water and hexane

출처 및 근거

ORD 기록
ord-6f46fe89a255440dbbea40f68a3b527e
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150588B2

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