Hydrochloric Acid → Cyclohexanone, 2-[(phenylmethoxy)methyl]-

HRID 1748171노트

반응식

HRID 1748171 반응식
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:19][CH2:18][CH2:17][CH2:16][C:11]21OCC[O:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH2:1]([O:8][CH2:9][CH:10]1[CH2:19][CH2:18][CH2:17][CH2:16][C:11]1=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 686237586-((Benzyloxy)methyl)-1,4-dioxaspiro[4.5]decane

생성물 1

HCID 10489011Cyclohexanone, 2-[(phenylmethoxy)methyl]-

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of 6-((Benzyloxy)methyl)-1,4-dioxaspiro[4.5]decane (2.4 g 9.1 mmol) in acetone (40 mL) was treated with 1.5N HCl (18 mL) and stirred at rt for 5 hours. The reaction mixture was neutralized with aqueous sodium carbonate and the volatile removed in vacuo. The residue was extracted with Et2O (3×50 mL) and the combined organic layer were washed with water (30 mL), brine (30 mL) and dried over sodium sulfate and concentrated to yield the desired product as pale yellow oil that was used in the next step without further purification. MS m/z 219.1 (M+1).

후처리

  1. customthe volatile removed in vacuo
  2. extractionThe residue was extracted with Et2O (3×50 mL)
  3. washthe combined organic layer were washed with water (30 mL), brine (30 mL)
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5c7a327edd30448b824639d9178071f1
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150568B2

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