Ethanol → 1-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid

HRID 1748437노트

반응식

HRID 1748437 반응식
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][N:13]=2)[C:10]=1[CH3:11])=[O:5])C.C(O)C.[OH-].[Na+]>O>[Br:18][C:15]1[CH:16]=[CH:17][C:12]([N:9]2[C:10]([CH3:11])=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[N:8]2)=[N:13][CH:14]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 46739344Ethyl 1-(5-bromopyridin-2-yl)-5-methylpyrazole-4-carboxylate

생성물 1

HCID 653475861-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid수율 63.1%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

1-(5-Bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (3.1 g) was added to ethanol (20 ml), water (10 ml) and 4N aqueous solution of sodium hydroxide (10 ml), stirred at 80° C. for five hours, and the solvent was evaporated in vacuo. 1N Hydrochloric acid aqueous solution was added to the residue at 0° C. and the precipitated solid was washed with water to give the titled compound (1.78 g) as a white solid.

후처리

  1. customthe solvent was evaporated in vacuo
  2. addition1N Hydrochloric acid aqueous solution was added to the residue at 0° C.
  3. washthe precipitated solid was washed with water

출처 및 근거

ORD 기록
ord-8f335b3d5c17488a86a3d2d352603016
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150555B2

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