Water → 3-Fluoro-2-hydrazinyl-5-(trifluoromethyl)pyridine
반응식
O.[NH2:2][NH2:3].F[C:5]1[C:10]([F:11])=[CH:9][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:7][N:6]=1.O>C(O)C>[F:11][C:10]1[C:5]([NH:2][NH2:3])=[N:6][CH:7]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:9]=1참가 물질
5
실험 절차
To a solution of hydrazine hydrate (100%) (3.45 ml) in ethanol (150 ml) was added dropwise a solution of 2,3-difluoro-5-(trifluoromethyl)pyridine (4.45 g) in ethanol (50 ml) at room temperature, stirred at the same temperature for 2 hours, and then additionally stirred at 80° C. for 2 hours. Then, the mixture was allowed to cool, water was added thereto, and the organic solvent was evaporated in vacuo. The precipitated solid was collected by filtration, and washed with water to give 3-fluoro-5-(trifluoromethyl)pyridin-2-ylhydrazine as a white solid.
후처리
- stirringadditionally stirred at 80° C. for 2 hours
- temperatureto cool
- customthe organic solvent was evaporated in vacuo
- filtrationThe precipitated solid was collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-dbc2f79b9a6c4bc5931dbe069eb53496
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09150555B2
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