Potassium Carbonate → 5-bromo-2-(tetrahydro-2H-pyran-4-yl)pyridine
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2(C#N)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+]>Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:7]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
4-(5-Bromopyridin-2-yl)tetrahydro-2H-pyran-4-carbonitrile (2 g) described in Reference Example 87 in concentrated hydrochloric acid (10 ml) was stirred at 100° C. for 3 days. After completion of the reaction, a saturated aqueous solution of potassium carbonate was added to alkalify the mixture, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated to give the titled compound (1.05 g) as a white solid.
후처리
- customAfter completion of the reaction
- extractionextracted with ethyl acetate
- dry with materialThe organic layer was dried over anhydrous magnesium sulfate
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-bf40929f083e4d4c98976e74897962a2
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09150555B2
반응 노트
불러오는 중…