Cesium carbonate → 5-Methyl-N-{5-methyl-6-[4-(3-oxomorpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

반응식

Br[C:2]1[CH:3]=[C:4]([CH3:21])[C:5]([C:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][C:15]3=[O:20])[CH2:10][CH:9]=2)=[N:6][CH:7]=1.[CH3:22][C:23]1[N:27]([C:28]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][N:29]=2)[N:26]=[CH:25][C:24]=1[C:38]([NH2:40])=[O:39].C(=O)([O-])[O-].[Cs+].[Cs+].[Cl-].[NH4+]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C1(P(C2C=CC=CC=2)C2C3OC4C(=CC=CC=4P(C4C=CC=CC=4)C4C=CC=CC=4)C(C)(C)C=3C=CC=2)C=CC=CC=1.O1CCOCC1>[CH3:22][C:23]1[N:27]([C:28]2[CH:33]=[CH:32][C:31]([C:34]([F:36])([F:37])[F:35])=[CH:30][N:29]=2)[N:26]=[CH:25][C:24]=1[C:38]([NH:40][C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][C:15]3=[O:20])[CH2:10][CH:9]=2)=[C:4]([CH3:21])[CH:3]=1)=[O:39]