Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-(6-chloro-5-cyanopyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 5-Amino-2-chloropyridine-3-carbonitrile | HCID 20496209 | — |
| 반응물 | 5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid chloride | HCID 89734997 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N-(6-chloro-5-cyanopyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide | HCID 86692611 | 195.8% |
반응 단계
5-Methyl-1-(5-(trifluoro methyl)pyridin-2-yl)-1H-pyrazole-4-carboxylic acid chloride (200 mg) and 5-amino-2-chloro-3-cyanopyridine (228 mg) were dissolved in pyridine (10 ml) and stirred at room temperature. After completion of the reaction, water was added to the reaction solution, the precipitated solid was collected by filtration and dried under heating and blow to give N-(6-chloro-5-cyanopyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (550 mg) as a light brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09150555B2 |
| 출처 데이터셋 | uspto-grants-2015_10 |
| ORD ID | ord-79ace4301b51486bb49e09edddddf152 |
| 출처 메모 | uspto-grants-2015_10 |