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Pyridine → 5-Methyl-N-{5-methyl-6-[1-(2-methylpropanoyl)piperidin-4-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

HRID 1748682
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인쇄 미리보기

반응식

HRID 1748682 반응식
[CH3:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].[CH3:7][C:8]1[N:12]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][N:14]=2)[N:11]=[CH:10][C:9]=1[C:23]([NH:25][C:26]1[CH:27]=[N:28][C:29]([CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[C:30]([CH3:32])[CH:31]=1)=[O:24].N1C=CC=CC=1.C(N(CC)CC)C>C(O)C.O>[CH3:7][C:8]1[N:12]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:21])([F:22])[F:20])=[CH:15][N:14]=2)[N:11]=[CH:10][C:9]=1[C:23]([NH:25][C:26]1[CH:27]=[N:28][C:29]([CH:33]2[CH2:34][CH2:35][N:36]([C:3](=[O:4])[CH:2]([CH3:6])[CH3:1])[CH2:37][CH2:38]2)=[C:30]([CH3:32])[CH:31]=1)=[O:24]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 1049PyridineHCID 8471TriethylamineHCID 62325Isobutyryl chlorideHCID 866925445-Methyl-N-[5-methyl-6-(piperidin-4-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

생성물 1

HCID 866926305-Methyl-N-{5-methyl-6-[1-(2-methylpropanoyl)piperidin-4-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

2-Methylpropanoylchloride (79 μl) was added to a mixture of 5-methyl-N-[5-methyl-6-(piperidin-4-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (222 mg) described in Reference Example 171 and pyridine (2.5 ml), and stirred at 40° C. for five hours. Triethylamine (350 μl), water and ethanol were added to the reaction solution, and the precipitated solid was washed with water to give the titled compound (220 mg) as a white solid.

후처리

  1. washthe precipitated solid was washed with water

출처 및 근거

ORD 기록
ord-c7ad1d0cd07a4315a5626b736fd3f7cb
출처 데이터셋
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09150555B2

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