Acetic Anhydride → N-[2-(tert-Butoxycarbonylmethylamino)ethyl]-N-methylacetamide

HRID 17494노트

반응식

HRID 17494 반응식
C(OC(=O)C)(=[O:3])C.[CH2:8]([N:10]([CH2:13][CH3:14])[CH2:11][CH3:12])C.[C:15]([O:19][C:20]([CH2:22][NH:23]CCNC)=[O:21])([CH3:18])([CH3:17])[CH3:16]>ClCCl>[C:15]([O:19][C:20]([CH2:22][NH:23][CH2:12][CH2:11][N:10]([CH3:8])[C:13](=[O:3])[CH3:14])=[O:21])([CH3:18])([CH3:17])[CH3:16]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 59921864HCID 59921864, 화합물

생성물 1

HCID 86630858N-[2-(tert-Butoxycarbonylmethylamino)ethyl]-N-methylacetamide수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Under nitrogen atmosphere, acetic anhydride (1.16 ml, 12.3 mmol) and triethylamine (2.28 ml, 16.4 mmol) were added to a dichloromethane (41 ml) solution of [2-(tert-butoxycarbonylmethylamino)ethyl]methylamine (I-202) (1.54 g, 8.18 mmol) with cooling with ice, followed by stirring at room temperature for 15 hours. The solvent was evaporated away under reduced pressure, then the resulting residue was subjected to silica gel column chromatography, and the eluate with dichloromethane/methanol (10:1, v/v) gave the entitled compound (1.88 g, 100%) as a colorless oil.

후처리

  1. temperaturewith cooling with ice
  2. customThe solvent was evaporated away under reduced pressure

출처 및 근거

ORD 기록
ord-422600918c5448baa5b1af786fee5d8d
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

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