Dichloromethane → 7-Fluoro-5-methyl-6-phenyl-2-(pyridin-3-yl)-1,3-benzoxazole-4-carbonitrile

HRID 17499

반응식

HRID 17499 반응식
Cl.[CH2:2](Cl)[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1.C(N(CC)CC)C.ClCCl.[NH2:20][C:21]1[C:26]([OH:27])=[C:25]([F:28])[C:24]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:23]([CH3:35])[C:22]=1[C:36]#[N:37]>C(OCC)(=O)C>[F:28][C:25]1[C:24]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:23]([CH3:35])[C:22]([C:36]#[N:37])=[C:21]2[C:26]=1[O:27][C:2]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)=[N:20]2

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 860974464-Amino-3-cyano-6-fluoro-5-hydroxy-2-methylbiphenyl

생성물 1

HCID 685843947-Fluoro-5-methyl-6-phenyl-2-(pyridin-3-yl)-1,3-benzoxazole-4-carbonitrile

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Nicotinyl chloride hydrochloride (192 mg, 1.08 mmol) and triethylamine (301 μl, 2.16 mmol) were added to a dichloromethane (9 ml) solution of 4-amino-6-fluoro-5-hydroxy-2-methylbiphenyl-3-carbonitrile (I-41) (218 mg, 0.900 mmol), followed by stirring at room temperature for 2 hours. Ethyl acetate (100 ml) was added to the reaction liquid, followed by washing with water (50 ml) and saturated brine (50 ml).

후처리

  1. washby washing with water (50 ml) and saturated brine (50 ml)

출처 및 근거

ORD 기록
ord-b06515a8803d431d872f27a069688415
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

연결된 노트

불러오는 중…