Water → 7-iodo-6-methoxybenzofuran-3(2H)-one
반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[C:3]=1[I:12].[C:13](=O)([O-])[O-].[K+].[K+].CI.O>CN(C=O)C>[I:12][C:3]1[C:4]2[O:8][CH2:7][C:6](=[O:9])[C:5]=2[CH:10]=[CH:11][C:2]=1[O:1][CH3:13]참가 물질
6
실험 절차
A solution of 6-hydroxy-7-iodobenzofuran-3(2H)-one (2.58 g, 9.35 mmol) in DMF (37 mL) was added with potassium carbonate (1.55 g, 11.2 mmol) and methyl iodide (0.697 mL, 11.2 mmol), and the mixture was stirred at room temperature for 13 hours. The reaction mixture was added with water (400 mL), and the precipitated solid was collected by filtration to obtain 7-iodo-6-methoxybenzofuran-3(2H)-one (1.35 g, 49%).
후처리
- filtrationthe precipitated solid was collected by filtration
출처 및 근거
- ORD 기록
- ord-f4b3193167cb4c51a7e1184338971551
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09156827B2
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