1,4-Dibromobutane → HCID 68630196, 화합물

HRID 1750093노트

반응식

HRID 1750093 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([OH:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[Br:11][CH2:12][CH2:13][CH2:14][CH2:15]Br.C([O-])([O-])=O.[K+].[K+]>CCO>[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][O:10][C:8]1[CH:7]=[CH:6][C:5]2[S:1][CH:2]=[N:3][C:4]=2[CH:9]=1

참가 물질

5

반응물 3

HCID 80561,4-DibromobutaneHCID 11430Potassium CarbonateHCID 35965065-Benzothiazolol

생성물 1

HCID 68630196HCID 68630196, 화합물수율 39%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of intermediate 25 (206 mg, 1.4 mmol), 1,4-dibromobutane (0.5 mL, 4.2 mmol) and anhydrous K2CO3 (193 mg, 1.4 mmol) in EtOH (20 mL) was heated to reflux and stirred overnight. The yellow solid was filtered and purified by column chromatography (elution with PE/EtOAc=4:1) to afford 5-(4-bromobutoxy)benzo[d]thiazole (intermediate 26) (108 mg, 39%) as a yellow oil. HPLC: 99%, RT 3.426 min. MS (ESI) m/z 288.0 [M+H]+.

후처리

  1. temperaturewas heated
  2. temperatureto reflux
  3. filtrationThe yellow solid was filtered
  4. custompurified by column chromatography (elution with PE/EtOAc=4:1)

출처 및 근거

ORD 기록
ord-a02c0d8cf99e480684f93acaaf04fb81
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156822B2

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