Hydrochloric Acid → (S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride

HRID 1750184노트

반응식

HRID 1750184 반응식
C(OC(=O)[NH:7][C@H:8]([CH2:13][S:14](=[O:18])(=[O:17])[NH:15][CH3:16])[CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[CH3:16][NH:15][S:14]([CH2:13][C@@H:8]([NH2:7])[CH2:9][CH:10]([CH3:11])[CH3:12])(=[O:17])=[O:18]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86714402((S)-3-Methyl-1-methylsulfamoylmethyl-butyl)-carbamic acid tert-butyl ester

생성물 1

HCID 86714400(S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

105 mg of ((S)-3-Methyl-1-methylsulfamoylmethyl-butyl)-carbamic acid tert-butyl ester were dissolved in 2 ml of dioxane and reacted with 1.3 ml of 4M hydrochloric acid in dioxane at it for 16 h. The reaction was concentrated in vacuo and the resulting crude product was used without further purification. 60 mg (100%) of (S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride were obtained.

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe resulting crude product was used without further purification

출처 및 근거

ORD 기록
ord-b74da5948bf1434dae962c804cfef3db
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156796B2

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