N-Iodosuccinimide → 4-Chloro-5-iodo-2-methyl-7H-pyrrolo(2,3-d)pyrimidine

HRID 1750286노트

반응식

HRID 1750286 반응식
[Cl:1][C:2]1[C:3]2[CH:11]=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.[I:12]N1C(=O)CCC1=O>ClCCl>[Cl:1][C:2]1[C:3]2[C:11]([I:12])=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 109208984-CHLORO-2-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE

생성물 1

HCID 665707094-Chloro-5-iodo-2-methyl-7H-pyrrolo(2,3-d)pyrimidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (400 mg, 2.4 mmol) in dichloromethane (10 mL) was added N-iodosuccinimide (537 mg, 2.39 mmol). The mixture was stirred at room temperature for 2 hours, then washed with aqueous sodium sulfite solution, dried over sodium sulfate, filtered, and concentrated in vacuo to provide the product as a brown solid. Yield: 330 mg, 1.12 mmol, 47%. LCMS m/z 293.8[M+H+].

후처리

  1. washwashed with aqueous sodium sulfite solution
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-74f17f59bafd4ada96f0342e0110db1f
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156845B2

반응 노트

불러오는 중…