Sodium Hydroxide → 5-bromo-1-tert-butyl-1H-pyrazole-4-carboxylic acid
반응식
[Br:1][C:2]1[N:6]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:5]=[CH:4][C:3]=1[C:11]([O:13]CC)=[O:12].[OH-].[Na+]>C(O)C.C1COCC1>[Br:1][C:2]1[N:6]([C:7]([CH3:8])([CH3:9])[CH3:10])[N:5]=[CH:4][C:3]=1[C:11]([OH:13])=[O:12]참가 물질
5
실험 절차
A mixed solution of the compound (13.5 g, 49.07 mmol) obtained in step 2 and 1N aqueous sodium hydroxide solution (65 mL, 65.00 mmol) in ethanol (70 mL) and THF (70 mL) was stirred at 60° C. for 2.5 hr. The organic solvent was evaporated under reduced pressure, and water and 1N hydrochloric acid (70 mL) were added thereto. The precipitate was collected by filtration, and washed with diethyl ether and hexane to give 5-bromo-1-tert-butyl-1H-pyrazole-4-carboxylic acid (10.29 g, 41.6 mmol, 85%) as a white powder.
후처리
- customThe organic solvent was evaporated under reduced pressure, and water and 1N hydrochloric acid (70 mL)
- additionwere added
- filtrationThe precipitate was collected by filtration
- washwashed with diethyl ether and hexane
출처 및 근거
- ORD 기록
- ord-4b4d8d18a2cf4c4f98ea3d4c1637599e
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09156837B2
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