2-Fluoro-6-methoxybenzoic acid → Hydrochloric Acid

HRID 1750492

반응식

HRID 1750492 반응식
[ClH:1].N[C@H]1CCC[C@@H]1NC(=O)C1C=CC=CC=1[Cl:16].[NH2:18][C@H:19]1[CH2:23][CH2:22][CH2:21][C@@H:20]1[NH:24][C:25](=[O:31])OC(C)(C)C.[F:32][C:33]1[CH:41]=[CH:40][CH:39]=[C:38]([O:42][CH3:43])[C:34]=1C(O)=O.O1POPOP1>>[ClH:16].[ClH:1].[NH2:18][C@H:19]1[CH2:23][CH2:22][CH2:21][C@@H:20]1[NH:24][C:25](=[O:31])[C:34]1[C:38]([O:42][CH3:43])=[CH:39][CH:40]=[CH:41][C:33]=1[F:32]

참가 물질

6

반응물 4

HCID 27373602-Fluoro-6-methoxybenzoic acidHCID 17040218(1S,2S)-trans-N-Boc-1,2-cyclopentanediamineHCID 203981951,3,5,2,4,6-TrioxatriphosphinaneHCID 118308080N-[(1S,2S)-2-Aminocyclopentyl]-2-chlorobenzamide hydrochloride2회

생성물 2

HCID 313Hydrochloric AcidHCID 118308173N-[(1S,2S)-2-Aminocyclopentyl]-2-fluoro-6-methoxybenzamide hydrochloride

실험 절차

Prepared according to the procedure for N-[(1S,2S)-2-aminocyclopentyl]-2-chlorobenzamide hydrochloride (Intermediate 19) from tert-butyl N-[(1S,2S)-2-aminocyclopentyl]carbamate (CAS number 586961-34-4; 500 mg, 2.50 mmol), 2-fluoro-6-methoxybenzoic acid (CAS number 137654-21-8; 637 mg, 3.74 mmol) and 1,3,5,2,4,6-trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide (CAS number 68957-94-8; 50% in ethyl acetate, 2.2 ml, 3.74 mmol). Subsequent deprotection with HCl afforded the title compound.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-10a25820505e48a9a88e10d87de09b71
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156829B2

연결된 노트

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