Hydrochloric Acid → (1S,2S)-1-N-Methyl-1-N-[5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride

HRID 1750500노트

반응식

HRID 1750500 반응식
C[C:2]1[C:3]([NH:12][C@H:13]2[CH2:17][CH2:16][CH2:15][C@@H:14]2[NH:18]C(=O)OC(C)(C)C)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.[ClH:26].O1CCOC[CH2:28]1>CO>[ClH:26].[CH3:28][N:12]([C:3]1[CH:2]=[N:7][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:5][N:4]=1)[C@H:13]1[CH2:17][CH2:16][CH2:15][C@@H:14]1[NH2:18]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 118308261tert-Butyl N-[(1S,2S)-2-{[3-methyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]carbamate

생성물 1

HCID 118308127(1S,2S)-1-N-Methyl-1-N-[5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of tert-butyl N-[(1S,2S)-2-{[3-methyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]carbamate (480 mg, 1.332 mmol) in methanol (5 ml) was added HCl in 1,4-dioxane (4 M, 3.33 ml, 13.32 mmol). The reaction was stirred at room temperature overnight and then concentrated in vacuo, azeotropically distilled with toluene to afford the title compound.

후처리

  1. concentrationconcentrated in vacuo
  2. distillationazeotropically distilled with toluene

출처 및 근거

ORD 기록
ord-e0a6fbbe63ad405995005a973b29e01b
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156829B2

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