2-Bromobenzyl bromide → Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate

HRID 1750729노트

반응식

HRID 1750729 반응식
[N:1]1([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Br:18][C:19]1[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=1[CH2:21]Br.C(N(C(C)C)CC)(C)C>C(#N)C>[Br:18][C:19]1[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=1[CH2:21][N:4]1[CH2:3][CH2:2][N:1]([C:7]2[CH:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][CH:17]=2)[CH2:6][CH2:5]1

참가 물질

5

반응물 3

HCID 769652-Bromobenzyl bromideHCID 81531DiisopropylethylamineHCID 2761178Ethyl 4-(piperazin-1-yl)benzoate

생성물 1

HCID 16109102Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of Example 4A (23.43 g, 100.0 mmol), 2-bromobenzyl bromide (26.24 g, 105.0 mmol) and diisopropylethylamine (20.94 mL, 120.0 mmol) in acetonitrile (200 mL) was stirred at room temperature for two hours. The resulting precipitate was collected by filtration to give the desired product, which was used without further purification.

후처리

  1. filtrationThe resulting precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-c6ca4aa9caf348d09eed9f7b90a67c24
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156856B2

반응 노트

불러오는 중…