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Potassium Permanganate → 1-(2,4-diisopropyldibenzo[b,d]furan-3-yl)-2-phenyl-1H-imidazole

HRID 1750901
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HRID 1750901 반응식
[CH:1]([C:4]1[C:16]([N:17]2[CH2:21][CH2:20][N:19]=[C:18]2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:15]([CH:28]([CH3:30])[CH3:29])[C:7]2[O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[CH:5]=1)([CH3:3])[CH3:2].[Mn]([O-])(=O)(=O)=O.[K+]>C(#N)C.ClCCl>[CH:1]([C:4]1[C:16]([N:17]2[CH:21]=[CH:20][N:19]=[C:18]2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:15]([CH:28]([CH3:30])[CH3:29])[C:7]2[O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[CH:5]=1)([CH3:3])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 516875Potassium PermanganateHCID 584008541-(2,4-diisopropyldibenzo[b,d]furan-3-yl)-2-phenyl-4,5-dihydro-1H-imidazole

생성물 1

HCID 584008691-(2,4-diisopropyldibenzo[b,d]furan-3-yl)-2-phenyl-1H-imidazole수율 72%

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 6344Dichloromethane용매

실험 절차

1-(2,4-diisopropyldibenzo[b,d]furan-3-yl)-2-phenyl-4,5-dihydro-1H-imidazole (7.4 g, 18.66 mmol) was dissolved in 200 mL of acetonitrile and 100 mL of dichloromethane. Potassium Permanganate (5.90 g, 37.3 mmol) and Clay K10 (12 g, 30.7 mmol) were ground in a mortar. The solid was then added carefully to the solution. Heat was generated after a few minutes. The reaction was monitored by TLC. The reaction was quenched with methanol after 1.5 h. The reaction mixture was filtered through Celite. The solvent was evaporated and the residue was purified by column. 5.3 g (72% yield) of pure product was obtained.

후처리

  1. additionThe solid was then added carefully to the solution
  2. temperatureHeat
  3. waitwas generated after a few minutes
  4. customThe reaction was quenched with methanol after 1.5 h
  5. filtrationThe reaction mixture was filtered through Celite
  6. customThe solvent was evaporated
  7. customthe residue was purified by column

출처 및 근거

ORD 기록
ord-d640ad05ac1942e29ea79d3538c0a3a5
출처 데이터셋
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09156870B2

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