Hydrochloric Acid → 4-Dibenzofuranamine
반응식
[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[C:4]([NH:14]C(=O)C)=[CH:3][CH:2]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>CO>[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[C:4]([NH2:14])=[CH:3][CH:2]=1참가 물질
5
실험 절차
N-(dibenzo[b,d]furan-4-yl)acetamide (90 g, 400 mmol) was suspended in the mixture of concentrated HCl (240 mL) and methanol (240 mL). The reaction was refluxed for 2 h and then cooled to room temperature. Saturated sodium carbonate was used to neutralize the solution. The residue was collected by filtration and redissolved in DCM. After dried over sodium sulfate, the solution was concentrated to give dibenzo[b,d]furan-4-amine (67 g, 92% yield) as brown solid.
후처리
- temperatureThe reaction was refluxed for 2 h
- filtrationThe residue was collected by filtration
- dissolutionredissolved in DCM
- dry with materialAfter dried over sodium sulfate
- concentrationthe solution was concentrated
출처 및 근거
- ORD 기록
- ord-3da70b8dfe19424388ff7ae00b6e089f
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09156870B2
반응 노트
불러오는 중…