C[O:2][C:3](=[O:16])[C@@H:4]([NH:11][C:12]([O:14][CH3:15])=[O:13])[C@H:5]([O:7][CH:8]([F:10])[F:9])[CH3:6].[OH-].C[Sn+](C)C>ClC(Cl)C.C(OCC)(=O)C>[F:9][CH:8]([F:10])[O:7][C@H:5]([CH3:6])[C@H:4]([NH:11][C:12]([O:14][CH3:15])=[O:13])[C:3]([OH:16])=[O:2]To a solution of (2S,3R)-methyl-3-(difluoromethoxy)-2-(methoxycarbonylamino)butanoate (265 mg, 1.1 mmol) in dichloroethane (10 mL) was added trimethyltin hydroxide (1 g, 5.5 mmol) and the resulting mixture was heated to 80° C. for 1 hour. The reaction was cooled to room temperature, diluted with ethyl acetate, washed twice with 5% aqueous HCl solution and brine, dried (MgSO4) and concentrated. The resulting crude material (209 mg, 84%) was used without further purification.
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