Hydrochloric Acid → 7-Bromochromone

HRID 1751401노트

반응식

HRID 1751401 반응식
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:15])/[CH:10]=[CH:11]/N(C)C)=[C:5]([OH:16])[CH:4]=1>ClCCl>[Br:2][C:3]1[CH:4]=[C:5]2[C:6]([C:9](=[O:15])[CH:10]=[CH:11][O:16]2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 11737295(E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one

생성물 1

HCID 186867527-Bromochromone수율 100,000%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of concentrated hydrochloric acid (30 mL) was added to a solution of (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one (10.4 g, 38.5 mmol) in dichloromethane (250 mL). The mixture was heated at reflux for 30 minutes and cooled to room temperature. The aqueous phase was extracted with dichloromethane (20 mL). The combined organic phases were washed with saturated sodium bicarbonate (50 mL), dried over sodium sulfate and filtered. The solvent was removed under reduced pressure to yield 7-bromo-4H-chromen-4-one (8.7 g, 38.5 mol, 100%).

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 30 minutes
  3. extractionThe aqueous phase was extracted with dichloromethane (20 mL)
  4. washThe combined organic phases were washed with saturated sodium bicarbonate (50 mL)
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-7a1acb49fd9f44058ade568147b52fcd
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156823B2

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