1-Butyne → 2-But-1-ynyl-4-fluorophenylamine

HRID 1751794노트

반응식

HRID 1751794 반응식
O1[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[C:9](I)[CH:8]=1.C#CCC>[Cu](I)I.C(N(CC)CC)C>[C:2]([C:11]1[CH:12]=[C:7]([F:6])[CH:8]=[CH:9][C:10]=1[NH2:13])#[C:3][CH2:4][CH3:5]

참가 물질

6

반응물 3

HCID 78461-ButyneHCID 8028TetrahydrofuranHCID 27782834-Fluoro-2-iodoaniline

생성물 1

HCID 580803722-But-1-ynyl-4-fluorophenylamine

시약·촉매·용매 2

HCID 83717Copper iodide촉매HCID 8471Triethylamine용매

실험 절차

80 ml of tetrahydrofuran is placed under argon. 5 g 4-fluoro-2-iodophenylamine, 0.74 g dichlorobis(triphenylphosphine) palladium(II), 0.2 g copper iodide and 8.8 ml triethylamine are added. 4 g gaseous 1-butyne are passed through the suspension. The reaction mixture is stirred under argon for 15 hours at ambient temperature, then filtered through Celite and evaporated to dryness. 3.4 g product are obtained in the form of a solid. 1H NMR (400 MHz, DMSO): 2.45 (2H, q); 1.18 (3H, t).

후처리

  1. filtrationfiltered through Celite
  2. customevaporated to dryness

출처 및 근거

ORD 기록
ord-72be47ac980441c8a82a26bc0fd26d7d
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09161927B2

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