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Water → Tert-butyl 4-[(2-methoxyacetylamino)-methyl]-4-phenylpiperidine-1-carboxylate

HRID 1751805
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인쇄 미리보기

반응식

HRID 1751805 반응식
[NH2:1][CH2:2][C:3]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1.C(N(C(C)C)CC)(C)C.[CH3:31][O:32][CH2:33][C:34](Cl)=[O:35].O>ClCCl>[CH3:31][O:32][CH2:33][C:34]([NH:1][CH2:2][C:3]1([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:14])([CH3:15])[CH3:13])=[O:10])[CH2:5][CH2:4]1)=[O:35]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 96623Methoxyacetyl chlorideHCID 10565452Tert-butyl 4-(aminomethyl)-4-phenylpiperidine-1-carboxylate

생성물 1

HCID 58080361Tert-butyl 4-[(2-methoxyacetylamino)-methyl]-4-phenylpiperidine-1-carboxylate

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

3.7 g of commercial tert-butyl 4-aminomethyl-4-phenyl-piperidine-1-carboxylate and 3 ml diisopropylethylamine are placed in 30 ml dichloromethane. Then 2.25 ml methoxyacetyl chloride are slowly added. The reaction mixture is stirred at ambient temperature until there is no further reaction, then mixed with water. The organic phase is evaporated to dryness. 4.7 g product are obtained in the form of an oil.

후처리

  1. customno further reaction
  2. customThe organic phase is evaporated to dryness

출처 및 근거

ORD 기록
ord-4639d1afa19c47e5bb5d1faa82538097
출처 데이터셋
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09161927B2

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