Sodium Hydroxide → HCID 89767207, 화합물

HRID 1752515노트

반응식

HRID 1752515 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]2[S:24][CH:25]=[C:26]([C:28]([O:30]C)=[O:29])[N:27]=2)[CH2:18][CH2:17]1)=[O:13].[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]2[S:24][CH:25]=[C:26]([C:28]([OH:30])=[O:29])[N:27]=2)[CH2:18][CH2:17]1)=[O:13]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 89767420HCID 89767420, 화합물

생성물 1

HCID 89767207HCID 89767207, 화합물수율 43%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of compound 7 (1.85 mmoles) in MeOH (10 mL) aqueous 1M NaOH (3.7 mL) was added. The solution was refluxed overnight then the organic solvent was removed under vacuum, the residue was diluted with H2O and the pH was adjusted to 5 by adding 1M HCl. The mixture was kept at 4° C. overnight then the resulting solid was filtered, washed with fresh water and dried under vacuum to give 2-{[4-({[(5-Methoxy-1H-indazol-3-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}-1,3-thiazole-4-carboxylic acid 8 (43% yield).

후처리

  1. temperatureThe solution was refluxed overnight
  2. customthe organic solvent was removed under vacuum
  3. additionthe residue was diluted with H2O
  4. additionby adding 1M HCl
  5. filtrationthe resulting solid was filtered
  6. washwashed with fresh water
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-11444f69f27d4c0ba75d38de67be0217
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163013B2

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