Hydrochloric Acid → HCID 89767022, 화합물

HRID 1752519노트

반응식

HRID 1752519 반응식
[ClH:1].[Br:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1)=[O:13]>CCOCC.CO>[ClH:1].[Br:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1)=[O:13]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 89767452Tert-butyl 4-({[(5-bromo-1H-indazol-3-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

생성물 1

HCID 89767022HCID 89767022, 화합물수율 76%

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

2M HCl in Et2O (1.8 L) was added to a solution of compound tert-butyl 4-(aminomethyl)piperidine-1-carboxylate 11a (0.24 moles) in MeOH (500 mL). The mixture was stirred for 3 hours at room temperature then the resulting solid was filtered and dried to give 5-Bromo-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamide hydrochloride 11 b (76% yield).

후처리

  1. filtrationthe resulting solid was filtered
  2. customdried

출처 및 근거

ORD 기록
ord-a61cb7650da5463db61b05f77772520b
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163013B2

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