Sodium Azide → 1-(Azidomethyl)-4-(trifluoromethyl)benzene

HRID 1752556노트

반응식

HRID 1752556 반응식
[N-:1]=[N+:2]=[N-:3].[Na+].[F:5][C:6]([F:16])([F:15])[C:7]1[CH:14]=[CH:13][C:10]([CH2:11]Br)=[CH:9][CH:8]=1>CS(C)=O.C(OCC)(=O)C>[N:1]([CH2:11][C:10]1[CH:9]=[CH:8][C:7]([C:6]([F:5])([F:15])[F:16])=[CH:14][CH:13]=1)=[N+:2]=[N-:3]

참가 물질

5

반응물 2

HCID 33557Sodium AzideHCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzene

생성물 1

HCID 498459471-(Azidomethyl)-4-(trifluoromethyl)benzene

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 8857Ethyl Acetate용매

실험 절차

Sodium azide (2.30 g, 35.4 mmol) was added to a solution of 4-(trifluoromethyl)benzyl bromide (4.26 g, 17.8 mmol) dissolved in dimethyl sulfoxide (15 mL) and stirred at ambient temperature overnight. The mixture was diluted with ethyl acetate, washed with water and brine, and dried over sodium sulfate. After filtration, the solvent was removed under reduced pressure to afford the title compound. The crude product was used in the next step without further characterization.

후처리

  1. washwashed with water and brine
  2. dry with materialdried over sodium sulfate
  3. filtrationAfter filtration
  4. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-8799b9f656294b06ad3fcd74eccbaab3
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163007B2

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