Hydrochloric Acid → N-(5-Cyano-2-fluoro-4-methoxy-6-methylbiphenyl-3-yl)-2,2-dimethylpropionamide

HRID 17526노트

반응식

HRID 17526 반응식
[NH2:1][C:2]1[C:3]([O:18][CH3:19])=[C:4]([C:16]#[N:17])[C:5]([CH3:15])=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:7]=1[F:8].[C:20](Cl)(=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22].Cl>N1C=CC=CC=1>[C:16]([C:4]1[C:3]([O:18][CH3:19])=[C:2]([NH:1][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[C:7]([F:8])=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]=1[CH3:15])#[N:17]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 62493Pivaloyl chlorideHCID 860975095-Amino-6-fluoro-4-methoxy-2-methylbiphenyl-3-carbonitrile

생성물 1

HCID 86630868N-(5-Cyano-2-fluoro-4-methoxy-6-methylbiphenyl-3-yl)-2,2-dimethylpropionamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

5-Amino-6-fluoro-4-methoxy-2-methylbiphenyl-3-carbonitrile (I-236) (300 mg, 1.17 mmol) was dissolved in pyridine (3 ml), and under nitrogen atmosphere at 0° C., pivaloyl chloride (433 μl, 3.51 mmol) was dropwise added. After stirring at roam temperature for 20 hours, aqueous 1 M hydrochloric acid solution was added to the reaction liquid at 0° C. The solution was extracted twice with ethyl acetate. The organic layer was washed with saturated brine, then dried over anhydrous sodium sulfate.

후처리

  1. extractionThe solution was extracted twice with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate

출처 및 근거

ORD 기록
ord-b7d31a10c76446828935736c15535c06
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

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