Pyridine → 5-Bromo-2-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine

HRID 1752949노트

반응식

HRID 1752949 반응식
N1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][N:7]=2)=[N:4][N:3]=N1.N1C=CC=CC=1.[C:19](OCC)(=[O:21])[CH3:20]>C(OC(=O)C)(=O)C>[CH3:20][C:19]1[O:21][C:5]([C:6]2[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][N:7]=2)=[N:4][N:3]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 8857Ethyl AcetateHCID 234386835-Bromo-2-(2H-tetrazol-5-yl)pyridine

생성물 1

HCID 234386435-Bromo-2-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine수율 80%

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

실험 절차

In 130 ml of acetic anhydride was dissolved 8.6 g of 2-(tetrazol-5-yl)-5-bromopyridine prepared in the Preparation example 6. And then the solution was added with 15 ml of pyridine and stirred for 3 hours for reaction. The reaction mixture was added with ethyl acetate and extracted to separate organic layer. And then the organic layer was washed with water and brine. The organic layer was dehydrated, filtrated and concentrated in vacuo to give 7.3 g of the title compound. Yield 80%.

후처리

  1. customprepared in the Preparation example 6
  2. extractionextracted
  3. customto separate organic layer
  4. washAnd then the organic layer was washed with water and brine
  5. filtrationfiltrated
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-922b978cd7784d899d3e8bca634c9442
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163043B2

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