Sodium borohydride → 2-(3-iodo-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-methylpropan-1-ol

HRID 1753069노트

반응식

HRID 1753069 반응식
[I:1][C:2]1[C:6]2[CH:7]=[N:8][CH:9]=[CH:10][C:5]=2[N:4]([C:11]([CH3:17])([CH3:16])[C:12](OC)=[O:13])[CH:3]=1.[BH4-].[Na+]>CCO>[I:1][C:2]1[C:6]2[CH:7]=[N:8][CH:9]=[CH:10][C:5]=2[N:4]([C:11]([CH3:17])([CH3:16])[CH2:12][OH:13])[CH:3]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 90094007methyl 2-(3-iodo-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-methylpropanoate

생성물 1

HCID 900938832-(3-iodo-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-methylpropan-1-ol수율 39%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of methyl 2-(3-iodo-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-methylpropanoate (Preparation 67, 10.8 g, 31.38 mmol) in EtOH (100 mL) was added sodium borohydride (2.37 g, 62.8 mmol) and the reaction stirred at room temperature for 5 hours. The reaction was quenched by the addition of water (100 mL) and the phases separated through a phase separation cartridge. The organic layer was concentrated in vacuo to afford and orange oil that was triturated with ether to afford an orange solid as the title compound (3.86 g, 39%).

후처리

  1. customThe reaction was quenched by the addition of water (100 mL)
  2. customthe phases separated through a phase separation cartridge
  3. concentrationThe organic layer was concentrated in vacuo
  4. customto afford
  5. customorange oil that was triturated with ether

출처 및 근거

ORD 기록
ord-a8a52fafde3c43c385db4245911574f3
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163021B2

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